Should I be concerned if the ice melts in my injectable Tirzepatide package?
It is common for ice packs to melt during transit, especially during longer shipping times or warm weather. If the ice pack is melted when your package arrives, this does not necessarily indicate an issue with your shipment. You can follow the storage instructions included with your prescription to ensure your medication is stored appropriately once received.
Storage Guidelines
Factory-Sealed Medication
- Vials that remain sealed can be stored at room temperature (68°–80°F) for up to 21 days, based on the storage guidance provided with your prescription.
- This allowance helps accommodate normal shipping conditions.
After Opening
- Once the vial has been opened (seal pierced), it should be stored in the refrigerator at 36°–46°F (2°–8°C).
In Short
- Sealed medication: May remain at room temperature (68°–80°F) for up to 21 days
- Opened medication: Store in the refrigerator (36°–46°F)
If your ice pack is melted on arrival, you may place the medication in the refrigerator according to the instructions included with your prescription. If you have questions about temperature exposure or your specific shipment, your pharmacy or healthcare provider can offer additional guidance.

Compounded versions of tirzepatide are not FDA-approved. The FDA has not evaluated compounded tirzepatide for safety, effectiveness, or quality. Compounded medications may differ in formulation, strength, or supporting evidence from FDA-approved products.

This article is for general informational purposes only and does not provide medical advice, diagnosis or treatment for any specific person.
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