What Is Semaglutide (Injectable)?
Semaglutide is a prescription medication that has been FDA-approved in specific formulations to treat type 2 diabetes, and separately for chronic weight management (under brand names such as Wegovy®). These approved medications are administered by injection, usually once weekly, and are intended to be used alongside diet and exercise.
How It Works
Semaglutide belongs to a class of drugs called GLP-1 (Glucagon-Like Peptide-1) receptor agonists. In FDA-approved clinical trials, these medications have been shown to:
- Slow down stomach emptying, which can help reduce hunger.
- Help regulate appetite and reduce calorie intake.
- Improve metabolic function, including effects on blood sugar regulation.
When used with healthy diet and regular physical activity, injectable semaglutide in its FDA-approved forms has shown measurable weight loss in clinical studies. For example, in the STEP clinical trial program, some participants experienced average weight loss in the double digits (percentage of body weight) over many weeks of treatment.
Safety & Side Effects
Like all medications, injectable semaglutide can cause side effects. The most commonly reported are mild to moderate gastrointestinal issues, such as nausea, vomiting, or digestive discomfort. These effects often lessen over time as the body adjusts.
Serious adverse effects are rare but possible. That’s why injectable semaglutide should always be used under the supervision of a licensed healthcare provider who can monitor your health, adjust dosage if needed, and ensure it’s appropriate for your situation.
Important Note on Compounded Versions
If you are considering a compounded version of semaglutide (i.e., a formulation prepared by a compounding pharmacy rather than the FDA-approved brand), please understand that:
- Those compounded versions are not FDA-approved.
- The evidence for safety and efficacy comes from studies of FDA-approved semaglutide formulations, not compounded ones.
- Compounded semaglutide may be prescribed by licensed providers when medically appropriate, and if prepared under correct standards by licensed compounding pharmacies.