Estradiol is the most clinically studied hormone therapy available, and modern bioidentical transdermal formulations have a strong safety profile. In fact, in February 2026, the FDA updated its labeling for menopausal hormone therapy and removed several longstanding boxed warnings, reflecting decades of updated evidence. As with any medication, it may not be appropriate for everyone — which is why every Nuvella patient has a thorough clinical consultation before anything is prescribed. Your provider will review your health history and guide you toward the right treatment for you.