Some intranasal medications arrive as dry peptide powder and must be mixed with the supplied solution before administration. This process is called reconstitution.

If your medication requires reconstitution, follow these steps:

1. Wash your hands: Thoroughly wash your hands before handling the medication or mixing supplies.

2. Remove the spray top: Keep the bottle upright and carefully unscrew the nasal spray top, which has a clear tube attached. Avoid tipping the bottle or blowing into it.

3. Prepare the mixing solution: Locate the supplied 10 mL mixing solution syringe and twist off the rubber cap. Do not press the plunger until you are ready to add the solution.

4. Add the mixing solution: Insert the syringe tip into the bottle and slowly depress the plunger until all of the supplied mixing liquid has been added.

5. Replace the spray top: Carefully reinsert the spray top and tighten it securely.

6. Mix the medication: Swirl and shake the bottle for at least 60 seconds, until the powder has completely dissolved and the solution appears clear.

7. Prime the nasal spray: Point the spray away from your face and activate the pump approximately 3–5 times, until a fine mist appears.

8. Refrigerate: Return the medication to the refrigerator immediately after preparation. Do not freeze.

If the medication remains cloudy after mixing, allow it to sit for approximately two minutes before shaking again until the solution becomes clear.

Write the date of reconstitution on the bottle to help track the medication's expiration after mixing.

Important: Only mix one medication kit at a time. Unused kits should remain sealed and refrigerated until needed.